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Rafael Sánchez Parrilla

Laboratorio Clínico ICS Camp de Tarragona - Terres de l’Ebre.
Hospital Universitario Joan XXIII de Tarragona

Wednesday, 30 September 2020

BINUCLEATED LYNPHOCYTES CHARACTERISTIC OF POLYCLONAL B-CELL LYNPHOCYTOSIS

Written by Silvia Montolio Breva | Rafael Sánchez Parrilla | Isabel Fort Gallifa

LINFOCITOS BINUCLEADOS CARACTERÍSTICOS DE LINFOCITOSIS B POLICLONAL
Figure 1. Binucleated lymphocytes in peripherical blood smear (May-Grünwald-Giemsa) in a polyclonal b-cell lymphocytosis patient.

An image of an extension of peripheral blood smear, stained with May-Grünwald-Giemsa, is presented (figure 1). It is observed binucleated lymphocytes. These entities are constant and they are almost a exclusive feature of persistent polyclonal B lymphocytosis (LBPP). Morphologically, the lymphocytes are medium-large in size with a moderately condensed, bilobed nucleus, with a broad and slightly basophilic cytoplasm, as seen in the image. In addition, it is also common to observe the presence of lymphocytes with a central incisure nucleus, more or less deep that represents the different evolutionary stages prior to the binucleated lymphocyte (figure 2).