Óscar Fuster Lluch
Hospital Universitario y Politécnico La FE
Monday, 30 September 2019
Figure 1. Pappenheimer bodies in erythroblast and in hemocyte (Blood smear. May-Grünwald Giemsa stain).
We present an image of a peripheral blood smear, stained with May-Grünwald Giemsa (Figure 1). This picture shows erythrocytes with multiple inclusions of bluish, small and irregular granules that occupy a portion of the red blood cell. The inclusions described are also observed in erythroblasts, adopting a perinuclear disposition. These granules, suggestive of Pappenheimer bodies, are morphologically different from other visible inclusions with the same type of staining (Howell-Jolly and basophilic stippling). This corresponds to intracellular iron deposits which were evidenced later by Perls staining (Figure 2).