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María Santamaría González

Servicio de Bioquímica Clínica. Hospital Universitario Miguel Servet

Monday, 31 December 2018

EARLY DIAGNOSIS OF PORPHYRIAS IN ACUTE PHASE

Written by María Santamaría González | Nuria Antón Baltanás | Jorge Navarro Amesti, Posted in Volumen 9

DIAGNÓSTICO PRECOZ DE PORFIRIAS EN FASE AGUDA
Figure 1. The Images shown different urine samples from different patients after applying Hoesch test, it can be appreciated a red coloration in the positive acute porphyria sample.

A positive result of Hoesch Test is shown in the image. This test allows to confirm or rule out an acute attack of Porphyria. It is a simple, fast and cheap method that produces the immediate color of the urine in contact with Ehrlich reactive. This reactive can be easily prepared in the laboratory adding 42 ml of acetic acid (100%) and 8 ml of percloric acid (60%) to 1 grame of 4-dimetilamine-benzaldehyde. Hoesch test is done by addition of 2-3 drops of the urine to 1 ml of reactive in suspected cases of acute Porphyria.

Wednesday, 30 December 2020

LITHIASIS ON FOREIGN BODIES

Written by María Santamaría González | José Luis Bancalero Flores | Claudia Abadía Molina

LITIASIS SOBRE CUERPOS EXTRAÑOS
Figure 1. Lithiasis on suture thread in a 79-year-old man. A) and B) Lithiasis on suture thread. C) Fragment: 55% whewellite, 40% weddellite and 5% hydroxyapatite. D) Infrared spectrum (IRS) of organic matter. E) IRS corresponding to whewellite, weddellite, and hydroxyapatite.

The main cause of lithogenesis is supersaturation of some constituents in urine. Other factors as extreme pH, anatomical malformations or presence of promoters can facilitate this process too.