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María Santamaría González

Servicio de Bioquímica Clínica. Hospital Universitario Miguel Servet

Monday, 31 December 2018

EARLY DIAGNOSIS OF PORPHYRIAS IN ACUTE PHASE

Written by María Santamaría González | Nuria Antón Baltanás | Jorge Navarro Amesti, Posted in Volumen 9

DIAGNÓSTICO PRECOZ DE PORFIRIAS EN FASE AGUDA
Figure 1. The Images shown different urine samples from different patients after applying Hoesch test, it can be appreciated a red coloration in the positive acute porphyria sample.

A positive result of Hoesch Test is shown in the image. This test allows to confirm or rule out an acute attack of Porphyria. It is a simple, fast and cheap method that produces the immediate color of the urine in contact with Ehrlich reactive. This reactive can be easily prepared in the laboratory adding 42 ml of acetic acid (100%) and 8 ml of percloric acid (60%) to 1 grame of 4-dimetilamine-benzaldehyde. Hoesch test is done by addition of 2-3 drops of the urine to 1 ml of reactive in suspected cases of acute Porphyria.