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Wednesday, 30 December 2020

EDITORIAL - NAVIDADES CON SENTIDO

Written by Editores

EDITORIAL - NAVIDADES CON SENTIDO
Hace unos días me encontré en un debate improvisado con un ser querido sobre la posibilidad de “prohibir la Navidad”. A principios de diciembre oíamos en todas las noticias las graves consecuencias que había dejado tras su paso la celebración de Acción de Gracias en Estados Unidos, con récord de mortalidad y más de 100.000 hospitalizaciones en un sólo día. Por ello no parecía tan descabellado el intentar minimizar el impacto de una celebración de semejante calibre en nuestro país.

Wednesday, 30 December 2020

LITHIASIS ON FOREIGN BODIES

Written by María Santamaría González | José Luis Bancalero Flores | Claudia Abadía Molina

LITIASIS SOBRE CUERPOS EXTRAÑOS
Figure 1. Lithiasis on suture thread in a 79-year-old man. A) and B) Lithiasis on suture thread. C) Fragment: 55% whewellite, 40% weddellite and 5% hydroxyapatite. D) Infrared spectrum (IRS) of organic matter. E) IRS corresponding to whewellite, weddellite, and hydroxyapatite.

The main cause of lithogenesis is supersaturation of some constituents in urine. Other factors as extreme pH, anatomical malformations or presence of promoters can facilitate this process too.

Wednesday, 30 December 2020

PREMUTATION-COMPLETE MUTATION MOSAICISM IN FMR1 GENE: TRIPLET PRIMED REPEAT-PCR

Written by Paula Sienes Bailo | Raquel Lahoz Alonso | Silvia Izquierdo Álvarez

MOSAICISMO PREMUTACIÓN-MUTACIÓN COMPLETA EN EL GEN FMR1: TRIPLET PRIMED REPEAT-PCR
Figure 1. Electropherogram of a healthy male studied to rule out the carrier status of the CGG triplet expansion in the FMR1 gene after the identification of family history.

Figure 1, electropherogram of a healthy 53-year-old male studied to rule out the carrier status of the CGG triplet expansion in the FMR1 gene after the identification of the premutation in this gene in his three siblings. AmplideXTM FMR1 PCR Reagents (Asuragen) with CGG Repeat Primed PCR and analysis of the fragments using the ABI 3130xl sequencer and GeneMapper 4.0 software were used in this study. The Triplet Primed Repeat-PCR (TP-PCR) is a modification of the PCR, specific for the study of repeated areas.

Wednesday, 30 December 2020

EARLY DIAGNOSIS OF UROTHELIAL CARCINOMA BY ABNORMAL CELLS SEEN IN THE URINARY SEDIMENT

Written by Clara Esparza del Valle | Guillermo Velasco de Cos | Germán Moreno de Juan

DIAGNÓSTICO PRECOZ DE CARCINOMA VESICAL POR OBSERVACIÓN DE CÉLULAS NO HABITUALES EN SEDIMENTO URINARIO
Figure 1. Images taken in contrast phase (oc x10, obj x40). A) Cells grouped in nests and with great disproportion in nuclear size.  B) Cells with significant cytoplasmic nucleus disproportion.

Bladder cancer is the fifth most frequent cancer in men in developed countries, the principal risk factor is the smoking habit.
 
The treatments vary greatly depending on the stage in which the patient is, from simple transurethral resection, and intravesical BCG instillations to protocols with adjuvant chemotherapy or cystectomy in the most severe cases. The survival and quality of life of the patient depends largely on early diagnosis.

Wednesday, 30 December 2020

AN UNUSUAL DEBUT OF ACUTE LEUKEMIA

Written by Eva Barbón Alonso | Beatriz Villanueva Iribarren | María Ordóñez Marina

DEBUT INUSUAL DE LEUCEMIA AGUDA
Figure 1. May-Grünwald-Giemsa staining picture taken with Cellavision® of peripheral blood frame of the patient, showing blasts with a high nuclear-to-cytoplasmic ratio and some nucleoli.

It is presented the case of an 89-year-old woman with sudden and non-transient onset of strength loss, disorientation and speech difficulties. The patient was presented to the nearest referral hospital, where initial examination showed dysphagia, facial asymmetry and severe headache, besides worsening of previous motor deficits.